Article

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancer

2023-09-14

Abstract excerpt

Immunogenic cell death (ICD), an immune-priming form of cell death, has been shown to be induced by several different anti-cancer therapies. Despite being the first and one of the most successful antibody-drug conjugates (ADCs) approved for refractory HER2-positive breast cancer, little is known if response and resistance to trastuzumab emtansine (T-DM1) involves ICD modulation that can be leveraged to enhance T-D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8338a90f-98b2-5c90-a58f-f5cf55248034
DOI: 10.1101/2023.09.12.557273

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reviving immunogenic cell death upon targeting TACC3 enhances T-DM1 response in HER2-positive breast cancerDOI 10.1101/2023.09.12.557273Read

Patritumab deruxtecan induces immunogenic cell deathSemantic proximity Read

Pan-cancer Analyses of Immunogenic Cell Death-derived Gene Signatures: Potential Biomarkers for Prognosis and ImmunotherapySemantic proximity Read

Molecular and Translational Classifications of DAMPs in Immunogenic Cell DeathSemantic proximity Read

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast CancersSemantic proximity Read

CHA1: A New Combinatorial Therapy That Reciprocally Regulates Wnt and JAK/STAT/Interferon Signaling to Re-program Breast Tumors and the Tumor-Resident LandscapeSemantic proximity Read

ACB1801 enhances tumor immunogenicity by targeting glycolysis/ferroptosis vulnerability and activating STAT1-signaling to overcome anti-PD-1 resistance in MSS colorectal cancerSemantic proximity Read

Clinical application of immunogenic cell death inducers in cancer immunotherapy: turning cold tumors hotSemantic proximity Read

Improve the Efficacy of B7-H3-Targeting Antibody-Drug Conjugate DS-7300a in TP53-deficient Tumors by Inducing FerroptosisSemantic proximity Read

Immunogenic Cell Death and Immunotherapy of Multiple MyelomaSemantic proximity Read

Targeting MICA/B with cytotoxic therapeutic antibodies leads to tumor controlSemantic proximity Read

The Unfolded Protein Response in Immunogenic Cell Death and Cancer ImmunotherapySemantic proximity Read

Development of a novel HER2-CAR monocyte cell therapy with controllable proliferation and enhanced anti-tumor efficacySemantic proximity Read