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Article

Role of positive selection pressure on the evolution of H5N1 hemagglutinin.

Genomics, proteomics & bioinformatics - 1 Jun 2009

Duvvuri Venkata R S K, Duvvuri Bhargavi, Cuff Wilfred R, Wu Gillian E, Wu Jianhong

Abstract excerpt

The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure on HA of H5N1 influenza A virus was analyzed using bioinformatics algorithms. Most of the identified positive selection (PS) sites were found to be within or adjacent to epitope sites. Some of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19591791
DOI: 10.1016/S1672-0229(08)60032-7
PMCID: PMC5054228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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