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DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-catenin

11 Jan 2022

Abstract excerpt

DNA topoisomerase II alpha (TOP2A) reportedly plays a crucial role in several cancers, however, the precise regulatory role of TOP2A in metastatic characteristics of glioma is still poorly understood. Herein, we sought to elucidate the mechanisms by which TOP2A affects the metastatic phenotypes of glioma. We observed that a high level of TOP2A expression was dramatically linked with inferior survival in glioma...

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Cancer Mechanisms and Therapy
Cancer therapeutics and mechanisms
Glioma Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35012441
DOI: 10.1080/21655979.2021.2023985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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DNA topoisomerase II alpha promotes the metastatic characteristics of glioma cells by transcriptionally activating β-cateninPMID 35012441Read ↗

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