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Article

UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

8 Jul 2025

Abstract excerpt

PURPOSE: High-grade glioma is the most aggressive form of primary brain tumor, characterized by rapid progression and a grim prognosis. The presence of mutations in IDH1 and TP53 is associated with a specific molecular phenotype in glioma, and their interaction is a potential target for therapy. EXPERIMENTAL DESIGN: Our study utilized a combination of bioinformatics analysis, in vitro experiments, and in vivo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40627452
DOI: 10.1158/1078-0432.ccr-25-0261

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UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant GliomaPMID 40627452Read ↗

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