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Real‐time longitudinal analysis of human gliomas reveals in vivo genome evolution and therapeutic impact under standardized treatment

1 Jul 2022

Abstract excerpt

The molecular characterization of glioma genes is essential for properly managing and treating this heterogeneous disease.1, 2 However, the true in vivo evolution of the genome of glioma patients during treatment and its impact on clinical outcomes is unclear.3 Here, we have performed an in-depth analysis of ctDNA from patients’ tumour in situ fluid (TISF)4 samples at baseline (BL), disease progression, and...

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PMID: 35802830
DOI: 10.1002/ctm2.956

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