Article

A G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

2021-02-22

Abstract excerpt

<h4>Summary</h4> Adolescent idiopathic scoliosis (AIS) is the most common spine disorder affecting children worldwide, yet little is known about the pathogenesis of this disorder. Here, we demonstrate that genetic regulation of structural components of the axial skeleton, the intervertebral discs and dense connective tissues (e.g., ligaments and tendons), are essential for maintenance of spinal alignment. We show...

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Literature Corpus work: 248825b8-da17-5115-95ff-d788ded0d986
DOI: 10.1101/2021.02.22.432353

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