Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.

PLoS genetics - 1 Oct 2019

Liu Zhaoyang, Easson Garrett W D, Zhao Jingjing, Makki Nadja, Ahituv Nadav, Hilton Matthew J, Tang Simon Y, Gray Ryan S

Abstract excerpt

Degenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide and has been attributed primarily to trauma and the accumulation of pathology during aging. While genetic defects have also been associated with disc degeneration, the precise mechanisms driving the initiation and progression of disease have remained elusive due to a paucity of genetic animal models....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Plate

Share to Intervertebral Disc

Share to Intervertebral Disc Degeneration

Share to Intervertebral Disc Displacement

Share to Receptors, G-Protein-Coupled

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 31652254
DOI: 10.1371/journal.pgen.1008096
PMCID: PMC6834287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice.PMID 31652254Read ↗

Homeostasis of the intervertebral disc requires regulation of STAT3 signaling by the adhesion G-protein coupled receptor ADGRG6Semantic proximity Read ↗

An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignmentSemantic proximity Read ↗

A G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignmentSemantic proximity Read ↗

Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.Semantic proximity Read ↗

Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease.Semantic proximity Read ↗

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read ↗

Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.Semantic proximity Read ↗

HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia.Semantic proximity Read ↗

Comparison of inbred mouse strains shows diverse phenotypic outcomes of intervertebral disc aging.Semantic proximity Read ↗

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis.Semantic proximity Read ↗

PRSS56 is required for the developmental positioning of ocular angle structuresSemantic proximity Read ↗

Cartilage and bone changes during development of post-traumatic osteoarthritis in selected LGXSM recombinant inbred mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.