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Article

FLNB and TTC26 regulate ciliary Hedgehog signaling to maintain intervertebral disc matrix homeostasis in adolescent idiopathic scoliosis.

Genome biology - 25 May 2026

Jiang Heng, Gao Yuan, Lai Bowen, Wu Jinhui, Liao Taotao, Zhang Zheng, Zhou Xin, Zhao Jianquan, Meng Yichen, Cai Zhuyun, Zhang Chenglin, Lai Suomei, Gao Rui, Wang Ce, Li Jinsong, Yang Fu, Ding Yifu, Zhou Xuhui

Abstract excerpt

BACKGROUND: Adolescent idiopathic scoliosis (AIS) is a complex spinal deformity with evidence of contributions from multiple genetic factors, but the molecular basis of gene-gene interactions in its development remains unclear. Filamin B (FLNB) and tetratricopeptide repeat domain 26 (TTC26) have both been implicated in the regulation of primary cilia and extracellular matrix homeostasis. However, whether combined...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42178579
DOI: 10.1186/s13059-026-04107-w
PMCID: PMC13471262

Genes

FLNB
GLI2
PRMT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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