Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.

Human molecular genetics - 1 Aug 2015

Karner Courtney M, Long Fanxin, Solnica-Krezel Lilianna, Monk Kelly R, Gray Ryan S

Abstract excerpt

Adolescent idiopathic scoliosis (AIS) and pectus excavatum (PE) are common pediatric musculoskeletal disorders. Little is known about the tissue of origin for either condition, or about their genetic bases. Common variants near GPR126/ADGRG6 (encoding the adhesion G protein-coupled receptor 126/adhesion G protein-coupled receptor G6, hereafter referred to as GPR126) were recently shown to be associated with AIS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cartilage
Share to Chondrocytes
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Receptors, G-Protein-Coupled

Share to Scoliosis

Share to Sulfotransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 25954032
DOI: 10.1093/hmg/ddv170
PMCID: PMC4492399

Genes

ADGRG6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.PMID 25954032Read ↗

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.Semantic proximity Read ↗

Association of GPR126 gene polymorphism with adolescent idiopathic scoliosis in Chinese populations.Semantic proximity Read ↗

Genetic Variant of GPR126 Gene is Functionally Associated With Adolescent Idiopathic Scoliosis in Chinese Population.Semantic proximity Read ↗

A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis PopulationSemantic proximity Read ↗

Regulation of body length and bone mass by Gpr126/Adgrg6.Semantic proximity Read ↗

The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.Semantic proximity Read ↗

Arhgap29 Deficiency Directly Leads to Systemic and Craniofacial Skeletal AbnormalitiesSemantic proximity Read ↗

A G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignmentSemantic proximity Read ↗

Structural basis for adhesion G protein-coupled receptor Gpr126 functionSemantic proximity Read ↗

An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignmentSemantic proximity Read ↗

Massively parallel characterization of adolescent idiopathic scoliosis risk variantsSemantic proximity Read ↗

A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.