License to cut: Smart RNA guides for conditional control of CRISPR-Cas9

Abstract excerpt

The Cas9 enzyme is a programmable endonuclease, whose target sequence is directed by a companion RNA guide. Cas9 and RNA guides have revolutionized biology, enabling facile editing of the genome in almost all organisms. Controlling where and when Cas9 and the guide operate is indispensable for many fields ranging from developmental biology to therapeutics, but it remains a challenge. Most methods focus on controll...

Topics

Open a Topic to create a Post that cites this publication.

• Aptamers, Nucleotide
• CRISPR-Associated Proteins
• CRISPR-Cas Systems
• Gene Editing
• Mice
• Mutation
• Ribonucleases
• RNA

Identifiers and source

Literature Corpus work

247e63b9-60a1-5e78-8b46-86e09d77cc94

DOI

10.1101/2022.10.26.513620