Article

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

2019-03-13

Abstract excerpt

<h4>Background</h4> Consistent with their assumed mechanism of action, PARP inhibitors show significant therapeutic efficacy in breast, ovarian and prostate cancer, which are the solid tumor types most often associated with the loss of function of key homologous recombination genes. It remains unknown, however, how frequent homologous recombination deficiency (HRD) is in other solid tumor types. Since it is well...

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Literature Corpus work: 08c5f327-a667-5cd7-9be5-76ecbe833be4
DOI: 10.1101/576223

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