Article
Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets.
BMC cancer - 3 Jan 2022
Lai Zhongwu, Brosnan Matthew, Sokol Ethan S, Xie Mingchao, Dry Jonathan R, Harrington Elizabeth A, Barrett J Carl, Hodgson Darren
Abstract excerpt
BACKGROUND: DNA repair deficiencies are characteristic of cancer and homologous recombination deficiency (HRD) is the most common. HRD sensitizes tumour cells to PARP inhibitors so it is important to understand the landscape of HRD across different solid tumour types. METHODS: Germline and somatic BRCA mutations in breast and ovarian cancers were evaluated using sequencing data from The Cancer Genome Atlas (TCGA)...
Topics
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Databases, Genetic
- Datasets as Topic
- Female
- Genomics
- Germ-Line Mutation
- Homologous Recombination
- Humans
- Loss of Heterozygosity