Article
Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration.
Signal transduction and targeted therapy - 6 Feb 2023
She Kaiqin, Liu Yi, Zhao Qinyu, Jin Xiu, Yang Yiliu, Su Jing, Li Ruiting, Song Li, Xiao Jianlu, Yao Shaohua, Lu Fang, Wei Yuquan, Yang Yang
Abstract excerpt
The prime editor (PE) can edit genomes with almost any intended changes, including all 12 possible types of base substitutions, small insertions and deletions, and their combinations, without the requirement for double strand breaks or exogenous donor templates. PE demonstrates the possibility of correcting a variety of disease-causing mutations and might expand the therapeutic application of gene editing. In...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.