Article

SunTag-PE: a modular prime editing system enables versatile and efficient genome editing

2023-01-15

Abstract excerpt

Prime editing (PE) holds tremendous potential in the treatment of genetic diseases because it can install any desired base substitution or local insertion/deletion. However, the full-length PE effector size (6.3-kb) was beyond the packaging capacity of adeno-associated virus (AAV), hindering its clinical transformation. Various splitting strategies have been used to improve its delivery, but always accompanied by...

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Literature Corpus work: 1be0d16a-6c60-5b66-967d-58548f50cf68
DOI: 10.1101/2023.01.13.524016

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