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The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

2022-02-12

Abstract excerpt

Antimicrobial peptides (AMPs) offer a promising solution to the antibiotic resistance crisis. However, an unresolved serious concern is that the evolution of resistance to therapeutic AMPs may generate cross-resistance to host AMPs, compromising a cornerstone of the innate immune response. We systematically tested this hypothesis using globally disseminated mobile colistin resistance (MCR) that has been selected b...

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Identifiers and source

Literature Corpus work
4a569f99-0cfd-522c-8c5a-a7b1ebd18a90
DOI
10.1101/2022.02.12.480185
Open publication

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The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulenceDOI 10.1101/2022.02.12.480185
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