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Article

Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action.

Nature communications - 16 Dec 2019

Kintses Bálint, Jangir Pramod K, Fekete Gergely, Számel Mónika, Méhi Orsolya, Spohn Réka, Daruka Lejla, Martins Ana, Hosseinnia Ali, Gagarinova Alla, Kim Sunyoung, Phanse Sadhna, Csörgő Bálint, Györkei Ádám, Ari Eszter, Lázár Viktória, Nagy István, Babu Mohan, Pál Csaba, Papp Balázs

Abstract excerpt

Antimicrobial peptides (AMPs) are key effectors of the innate immune system and promising therapeutic agents. Yet, knowledge on how to design AMPs with minimal cross-resistance to human host-defense peptides remains limited. Here, we systematically assess the resistance determinants of Escherichia coli against 15 different AMPs using chemical-genetics and compare to the cross-resistance spectra of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 31844052
DOI: 10.1038/s41467-019-13618-z
PMCID: PMC6915728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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