Article

Hierarchical control of cardiomyocyte maturation and ischaemia sensitivity by metabolic culture conditions

2026-03-15

Abstract excerpt

Ischaemic heart disease remains the leading cause of mortality worldwide, yet no therapies prevent cardiomyocyte death during acute ischaemia–reperfusion injury (IRI). Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) provide a platform for modelling cardiac injury, but their immature phenotype limits the physiological fidelity of in vitro models. Here, we systematically evaluated how experim...

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Literature Corpus work: 246bba90-fedc-59aa-b119-ac041955d3d9
DOI: 10.64898/2026.03.12.711459

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