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Article

Humanized hiPSC Platforms for I/R Injury: Advancing Toward Precision Cardioprotection.

Cardiovascular therapeutics - 1 Jan 2026

Mi Mengyan, Chen Tzu-Yu, Ye Honghua

Abstract excerpt

Myocardial ischemia-reperfusion (I/R) injury remains a major contributor to infarct expansion, adverse remodeling, and heart failure despite timely coronary revascularization. The repeated failure of cardioprotective interventions that were effective in animal models has exposed a persistent translational gap. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and engineered cardiac platforms...

Read the complete abstract on PubMed

Topics

Humans
Induced Pluripotent Stem Cells
Myocytes, Cardiac
Animals
Myocardial Reperfusion Injury
Microphysiological Systems

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Precision Medicine

Phenotype

Cardiotoxicity

Tissue Engineering

Source

Open in PubMed Open full text

Identifiers

PMID: 42742929
DOI: 10.1155/cdr/2729114
PMCID: PMC13577191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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