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Maturation of pluripotent stem cell-derived cardiomyocytes: limitations and challenges from metabolic aspects

8 Oct 2024

Abstract excerpt

Acute coronary syndromes, such as myocardial infarction (MI), lack effective therapies beyond heart transplantation, which is often hindered by donor scarcity and postoperative complications. Human induced pluripotent stem cells (hiPSCs) offer the possibility of myocardial regeneration by differentiating into cardiomyocytes. However, hiPSC-derived cardiomyocytes (hiPSC-cardiomyocytes) exhibit fetal-like calcium...

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PMID: 39380099
DOI: 10.1186/s13287-024-03961-4

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