Article

Molecular and Functional Analysis of Calcium Binding by a Cancer-linked Calreticulin Mutant

2025-06-27

Abstract excerpt

Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone with low affinity calcium binding sites in its C-terminal domain. This region is altered by somatic mutations in the CRT gene ( CALR ), which drive a subset of myeloproliferative neoplasms (MPN). Perturbations in ER calcium storage and signaling are reported for the MPN type I mutant, CRT Del52 , and are linked to disease pathogenesis. Using recombina...

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Literature Corpus work: 24630f80-060e-5fea-9a11-ccae65398eda
DOI: 10.1101/2025.06.25.661618

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