Mutated calreticulin retains structurally disordered C terminus that cannot bind Ca2+: some mechanistic and therapeutic implications

Abstract excerpt

Two very recent reports 1 , 2 made a tremendous breakthrough in our understanding of the molecular basis of myeloproliferative neoplasms (MPNs) without mutations in Janus kinase 2 ( JAK2 ) and myeloproliferative leukemia ( MPL ) virus oncogene genes. Klampfl et al. 1 and Nangalia et al. 2 independently identified recurrent somatic mutation in the calreticulin ( CALR ) gene exclusively in patients with JAK2 and...

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