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Calreticulin and cancer.

Cell research - 1 Jan 2021

Fucikova Jitka, Spisek Radek, Kroemer Guido, Galluzzi Lorenzo

Abstract excerpt

Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ buffer to assist correct protein folding within the ER. Besides favoring the maintenance of cellular proteostasis, these cell-intrinsic CALR functions support Ca2+-dependent processes, such as adhesion and integrin signaling, and ensure normal...

Topics

Antigen Presentation
Calreticulin
Humans
Mutation
Myeloproliferative Disorders
Neoplasms
Prognosis
Signal Transduction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32733014
DOI: 10.1038/s41422-020-0383-9
PMCID: PMC7853084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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