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Article

Mechanism of mutant calreticulin-mediated activation of the thrombopoietin receptor in cancers.

The Journal of cell biology - 5 Jul 2021

Venkatesan Arunkumar, Geng Jie, Kandarpa Malathi, Wijeyesakere Sanjeeva Joseph, Bhide Ashwini, Talpaz Moshe, Pogozheva Irina D, Raghavan Malini

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are frequently driven by mutations within the C-terminal domain (C-domain) of calreticulin (CRT). CRTDel52 and CRTIns5 are recurrent mutations. Oncogenic transformation requires both mutated CRT and the thrombopoietin receptor (Mpl), but the molecular mechanism of CRT-mediated constitutive activation of Mpl is unknown. We show that the acquired C-domain of CRTDel52 mediates...

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Identifiers

PMID: 33909030
DOI: 10.1083/jcb.202009179
PMCID: PMC8085772

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