Article
Effects of calreticulin mutations on cell transformation and immunity.
Journal of cellular and molecular medicine - 1 Apr 2023
Desikan Harini, Kaur Amanpreet, Pogozheva Irina D, Raghavan Malini
Abstract excerpt
Myeloproliferative neoplasms (MPNs) are cancers involving dysregulated production and function of myeloid lineage hematopoietic cells. Among MPNs, Essential thrombocythemia (ET), Polycythemia Vera (PV) and Myelofibrosis (MF), are driven by mutations that activate the JAK-STAT signalling pathway. Somatic mutations of calreticulin (CRT), an endoplasmic reticulum (ER)-localized lectin chaperone, are driver mutations...
Topics
- Humans
- Calcium
- Calreticulin
- Carcinogenesis
- CD8-Positive T-Lymphocytes
- Cell Transformation, Neoplastic
- Janus Kinase 2
- Mutation
- Myeloproliferative Disorders