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Calreticulin is a Critical Cell Survival Factor in Malignant Neoplasms

30 Sept 2019

Abstract excerpt

Calreticulin (CRT) is a high-capacity Ca2+ protein whose expression is up-regulated during cellular transformation and is associated with disease progression in multiple types of malignancies. At the same time, CRT has been characterized as an important stress-response protein capable of inducing immunogenic cell death (ICD) when translocated to the cell surface. It remains unclear why CRT expression is preserved...

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PMID: 31568485
DOI: 10.1371/journal.pbio.3000402

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