Article

MYC shapes ER-mitochondria calcium transfer by directly targeting <i>ITPR1</i> : implications for MYC-induced safeguard mechanisms and cancer

2024-08-28

Abstract excerpt

<h4>ABSTRACT</h4> The MYC and NMYC transcription factors (TFs) play a key role in cell proliferation and are overexpressed in most cancer cells. However, in normal cells their overexpression triggers safeguard mechanisms promoting cell death and cellular senescence, which are bypassed in cancer cells. The mechanisms of action of this TF family are only partially understood. Here, we reveal that in normal cells MY...

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Literature Corpus work: ff972927-93ea-53da-b7d6-460956b5086b
DOI: 10.1101/2024.08.28.610025

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MYC shapes ER-mitochondria calcium transfer by directly targeting <i>ITPR1</i> : implications for MYC-induced safeguard mechanisms and cancerDOI 10.1101/2024.08.28.610025Read

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