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Impact of Calreticulin and Its Mutants on Endoplasmic Reticulum Function in Health and Disease.

Progress in molecular and subcellular biology - 1 Jan 2021

Arshad Najla, Cresswell Peter

Abstract excerpt

The endoplasmic reticulum (ER) performs key cellular functions including protein synthesis, lipid metabolism and signaling. While these functions are spatially isolated in structurally distinct regions of the ER, there is cross-talk between the pathways. One vital player that is involved in ER function is the ER-resident protein calreticulin (CALR). It is a calcium ion-dependent lectin chaperone that primarily...

Topics

Calreticulin
Endoplasmic Reticulum
Genes, Regulator
Humans
Mutation
Myeloproliferative Disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34050866
DOI: 10.1007/978-3-030-67696-4_8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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