Article

Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progression

2026-02-09

Abstract excerpt

<title>Abstract</title> <p> Diffuse IDH-mutant astrocytomas are brain tumors typically diagnosed as low-grade but capable of progressing to higher grades. They exhibit three cellular states resembling astrocytes, oligodendrocytes, and neural progenitor (NPC) cells. Understanding their biology has been challenging due to the lack of relevant in vitro models. Here we established and extensively characterized four...

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Literature Corpus work: 08ec3efd-ebd3-520a-8f40-01d199eb7ace
DOI: 10.21203/rs.3.rs-8562257/v1

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