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Article

Heterogeneity of glial progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex.

Cell reports - 2 Mar 2021

Fu Yuanyuan, Yang Ming, Yu Hongmin, Wang Yicheng, Wu Xinglong, Yong Jun, Mao Yunuo, Cui Yueli, Fan Xiaoying, Wen Lu, Qiao Jie, Tang Fuchou

Abstract excerpt

The heterogeneity and molecular characteristics of progenitor cells, especially glial progenitors, in the developing human cerebral cortex remain elusive. Here, we find that EGFR expression begins to sharply increase after gestational week (GW) 20, which corresponds to the beginning stages of human gliogenesis. In addition, EGFR+ cells are mainly distributed in the germinal zone and frequently colocalize with the...

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PMID: 33657375
DOI: 10.1016/j.celrep.2021.108788

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