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NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolism

2022-05-28

Abstract excerpt

Two splicing variants exist in NFYA, which exhibits high expression in many human tumor types, and their expression balance is known to correlate with prognosis in breast cancer, but functional differences are still unclear. Here, we demonstrate that NFYAv1, the long-form variant, upregulates the transcription of ACACA and FASN, essential lipogenic enzymes, to enhance the malignant behavior of triple-negative brea...

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Identifiers and source

Literature Corpus work
244754cb-71ca-5318-b89f-f9551cb2f854
DOI
10.1101/2022.05.26.493660
Open publication

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NFYA promotes the malignant behavior of triple-negative breast cancer through the regulation of lipid metabolismDOI 10.1101/2022.05.26.493660
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