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Article

Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer.

Breast cancer research : BCR - 28 Nov 2023

Tan Zheqiong, Deme Pragney, Boyapati Keerti, Claes Britt S R, Duivenvoorden Annet A M, Heeren Ron M A, Tressler Caitlin M, Haughey Norman James, Glunde Kristine

Abstract excerpt

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype and leads to the poorest patient outcomes despite surgery and chemotherapy treatment. Exploring new molecular mechanisms of TNBC that could lead to the development of novel molecular targets are critically important for improving therapeutic options for treating TNBC. METHODS: We sought to identify novel therapeutic...

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Source

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Identifiers

PMID: 38017485
DOI: 10.1186/s13058-023-01742-0
PMCID: PMC10683240

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