Adipocyte-rich microenvironment promotes TNBC progression through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypes.

doi:10.1186/s13046-026-03769-5

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Article

Adipocyte-rich microenvironment promotes TNBC progression through SIRT6-associated ACSL5 dysregulation and lipid storage-associated phenotypes.

Journal of experimental & clinical cancer research : CR - 1 Jul 2026

Li Yingnan, Sun Xinyi, Peng Jing, Ma Teng, Liu Changgen, Wang Haibo

Abstract excerpt

BACKGROUND: Triple-negative breast cancer (TNBC) is highly aggressive and has strong metastatic potential, and effective targeted therapies remain limited. There is growing evidence that the adipocyte microenvironment plays an important role in tumor progression, but its specific mechanism remains to be studied. As a key enzyme for the activation of long-chain fatty acids, the role and regulatory mechanism of...

Read the complete abstract on PubMed

Topics

Humans
Female
Animals
Sirtuins
Coenzyme A Ligases
Mice
Triple Negative Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adipocytes

Tumor Microenvironment

Phenotype

Disease Progression

Cell Line, Tumor

Lipid Metabolism

Mice, SCID

Gene Expression Regulation, Neoplastic

Cell Proliferation

Source

Open in PubMed Open full text

Identifiers

PMID: 42387350
DOI: 10.1186/s13046-026-03769-5
PMCID: PMC13579850

Genes

ACSL5
SIRT6
TG
CPT1A
FASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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