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ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

2023-10-19

Abstract excerpt

Triple-Negative Breast Cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming has emerged as a major driver of breast cancer metastasis. Here, we unveil a strong association between the heightened expression of fatty acid metabolic enzyme, acyl-CoA synthetase 4 (ACSL4) and T...

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Literature Corpus work
c2220e84-7a84-59d5-9479-87e8d93ae1ac
DOI
10.1101/2023.10.16.562466
Open publication

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ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expressionDOI 10.1101/2023.10.16.562466
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