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Article

Mutant p53-R280K hijacks SREBP1 to promote fatty acid synthesis and breast cancer progression via FASN.

Molecular biology reports - 1 Aug 2026

Fang Yihui, Zhang Ting, Huang Menggentuya, Lin Jing, Ye Qinong

Abstract excerpt

BACKGROUND: Lipid metabolic reprogramming is a hallmark of cancer, in which fatty acid synthesis is crucial for the rapid proliferation and metastasis of cancer cells. The p53-R280K mutation drives aggressive cancer, yet its role in fatty acid synthesis remains unclear. METHODS: The CRISPR/CasRx technique was applied to knockdown endogenous mutant p53-R280K in MDA-MB-231 cells and wild-type p53 (WT-p53) in ZR75-1...

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Share to Cell Proliferation
Share to Disease Progression
Share to Fatty Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Lipogenesis

Share to Mice, Nude

Share to Sterol Regulatory Element Binding Protein 1

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 42541598
DOI: 10.1007/s11033-026-12527-x

Genes

FASN
MB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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