Back to search

Article

PVT1 acts as a molecular scaffold to mediate PPARγ transcription and promote macrophage reprogramming in triple-negative breast cancer

2024-11-07

Abstract excerpt

<title>Abstract</title> <p>Objective The long non-coding RNA (lncRNA) <italic>PVT1</italic> plays a significant role in regulating the development and progression of various cancers. However, its clinical relevance in triple-negative breast cancer (TNBC) and its immunoregulatory mechanisms in TNBC remain largely unexplored. Methods An orthotopic TNBC mouse model was established, and single-cell RNA sequencing w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
41bc942a-688a-5554-86cb-483c3d3642e2
DOI
10.21203/rs.3.rs-5329038/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PVT1 acts as a molecular scaffold to mediate PPARγ transcription and promote macrophage reprogramming in triple-negative breast cancerDOI 10.21203/rs.3.rs-5329038/v1
Single-cell Atlas reveals core function of CPVL/MSR1 expressing macrophages in the prognosis of triple-negative breast cancerSemantic proximity
Distinct Endothelial Phenotype Associates with Macrophage-Enriched Microenvironments in Triple-Negative Breast CancerSemantic proximity
Integration of single-cell and bulk transcriptome analyses unravels a macrophage-based gene signature for prognostication and treatment in triple-negative breast cancerSemantic proximity
Understanding tissue-resident macrophages unlocks the potential for novel combinatorial strategies in breast cancerSemantic proximity
Targeting cancer-associated adipocyte-derived CXCL8 inhibits triple-negative breast cancer progression and enhances the efficacy of anti-PD-1 immunotherapySemantic proximity
Bidirectional phenotypic transition in macrophages influences triple-negative breast cancer cell immune evasive patterns and response to chemotherapies in a co-culture spheroid model.Semantic proximity
Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMISemantic proximity
Integrated transcriptional analysis reveals macrophage heterogeneity and tumor-macrophage interactions in the progression of pancreatic ductal adenocarcinomaSemantic proximity
Integrating Bulk and Single-cell RNA-seq to Construct a Macrophage-related Prognostic Model for Prognostic Stratification in Triple-negative Breast CancerSemantic proximity
A CTL/M2 Macrophage-Related Four-Gene Signature Predicting Metastasis-Free Survival in Triple-Negative Breast Cancer Treated with Adjuvant RadiotherapySemantic proximity
NONO directs PKM2-mediated H3T11ph to promote triple-negative breast cancer metastasis by activating SERPINE1 expressionSemantic proximity
Heterogeneity and transcriptional drivers of triple-negative breast cancerSemantic proximity
Select a neighboring publication to make it the new centre.