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Human cell polyploidization: The good and the evil

8 Apr 2021

Abstract excerpt

Therapeutic resistance represents a major cause of death for most lethal cancers. However, the underlying mechanisms of such resistance have remained unclear. The polyploid cells are due to an increase in DNA content, commonly associated with cell enlargement. In human, they play a variety of roles in physiology and pathologic conditions and perform the specialized functions during development, inflammation, and...

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PMID: 33839294
DOI: 10.1016/j.semcancer.2021.04.005

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