Article

Conserved Chamber-Specific Polyploidy Maintains Heart Function in <i>Drosophila</i>

2023-02-12

Abstract excerpt

<h4>SUMMARY</h4> Developmentally programmed polyploidy (whole-genome-duplication) of cardiomyocytes is common across evolution. Functions of such polyploidy are essentially unknown. Here, we reveal roles for precise polyploidy levels in cardiac tissue. We highlight a conserved asymmetry in polyploidy level between cardiac chambers in Drosophila larvae and humans. In Drosophila , differential Insulin Receptor (I...

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Literature Corpus work: 79ec9871-b8c3-54b6-8378-481d88eeed9a
DOI: 10.1101/2023.02.10.528086

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