Article
LRRK2 activation in idiopathic Parkinson's disease.
Science translational medicine - 25 Jul 2018
Di Maio Roberto, Hoffman Eric K, Rocha Emily M, Keeney Matthew T, Sanders Laurie H, De Miranda Briana R, Zharikov Alevtina, Van Laar Amber, Stepan Antonia F, Lanz Thomas A, Kofler Julia K, Burton Edward A, Alessi Dario R, Hastings Teresa G, Greenamyre J Timothy
Abstract excerpt
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson's disease (PD). However, a potential role of wild-type LRRK2 in idiopathic PD (iPD) remains unclear. Here, we developed proximity ligation assays to assess Ser1292 phosphorylation of LRRK2 and, separately, the dissociation of 14-3-3 proteins from LRRK2. Using these proximity ligation assays, we show that wild-type LRRK2 kinase...
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