Article

Fetal Thymic Expression Defines the Immunogenicity of Tumor Associated Antigens

2026-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Tumor associated antigens (TAAs) are promising targets for cancer immunotherapy, yet their immunogenicity varies widely and remains poorly understood. Here, we show that the immunogenic potential of TAAs is largely shaped by their expression in the thymus, likely established during fetal development. By integrating single-cell transcriptomic data across fetal and postnatal thymic epithelial cell...

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Literature Corpus work: 83434f55-e992-5109-8de9-0e8ebdf7dbaa
DOI: 10.64898/2026.01.25.701584

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