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Article

Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease.

Nature communications - 22 Sept 2023

Lee Solhwi, Lee Kunhee, Bae Hyeonjin, Lee Kyungmin, Lee Junghwa, Ma Junhui, Lee Ye Ji, Lee Bo Ryeong, Park Woong-Yang, Im Se Jin

Abstract excerpt

Graft-versus-host disease (GvHD) is a severe complication of hematopoietic stem cell transplantation driven by activated allogeneic T cells. Here, we identify a distinct subset of T cell factor-1 (TCF1)+ CD8+ T cells in mouse allogeneic and xenogeneic transplant models of acute GvHD. These TCF1+ cells exhibit distinct characteristics compared to TCF1- cells, including lower expression of inhibitory receptors and...

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Identifiers

PMID: 37737221
DOI: 10.1038/s41467-023-41357-9
PMCID: PMC10516895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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