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BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors

7 Oct 2022

Abstract excerpt

Regulatory T (T reg ) cells suppress effective antitumor immunity in tumor-bearing hosts, thereby becoming promising targets in cancer immunotherapy. Despite the importance of T reg cells in tumor immunity, little is known about their differentiation process and epigenetic profiles in the tumor microenvironment (TME). Here, we showed that T reg cells in the TME of human lung cancers harbored a completely...

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PMID: 36206353
DOI: 10.1126/sciimmunol.abk0957

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