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Transcriptomic Divergence Between Prefrontal Cortex and Limbic Circuits in Human Aging

2026-01-20

Abstract excerpt

Cognitive aging is characterized by declines in executive functions, yet the molecular mechanisms underlying the dissociation between cortical control and emotional reactivity remain unclear. This article proposes a conceptual model based on divergent transcriptomic erosion in the prefrontal cortex (PFC) compared to the relative resilience of the limbic system. We summarize data showing that the PFC exhibits marke...

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Literature Corpus work
23e7a7ac-5309-5b10-9c21-9acce889746a
DOI
10.20944/preprints202601.1501.v1
Open publication

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Transcriptomic Divergence Between Prefrontal Cortex and Limbic Circuits in Human AgingDOI 10.20944/preprints202601.1501.v1
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