Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex.

doi:10.1016/j.celrep.2020.03.053

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Article

Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex.

Cell reports - 7 Apr 2020

Werling Donna M, Pochareddy Sirisha, Choi Jinmyung, An Joon-Yong, Sheppard Brooke, Peng Minshi, Li Zhen, Dastmalchi Claudia, Santpere Gabriel, Sousa André M M, Tebbenkamp Andrew T N, Kaur Navjot, Gulden Forrest O, Breen Michael S, Liang Lindsay, Gilson Michael C, Zhao Xuefang, Dong Shan, Klei Lambertus, Cicek A Ercument, Buxbaum Joseph D, Adle-Biassette Homa, Thomas Jean-Leon, Aldinger Kimberly A, O'Day Diana R, Glass Ian A, Zaitlen Noah A, Talkowski Michael E, Roeder Kathryn, State Matthew W, Devlin Bernie, Sanders Stephan J, Sestan Nenad

Abstract excerpt

Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to the variation in expression, and some neuropsychiatric disorder loci may exert their effects through this mechanism. To investigate these relationships, we present BrainVar, a unique resource of paired whole-genome and bulk tissue RNA sequencing from the dorsolateral prefrontal cortex of...

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PMID: 32268104
DOI: 10.1016/j.celrep.2020.03.053
PMCID: PMC7295160

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