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Evolution of the Aging Brain Transcriptome and Synaptic Regulation

1 Oct 2008

Abstract excerpt

Alzheimer's disease and other neurodegenerative disorders of aging are characterized by clinical and pathological features that are relatively specific to humans. To obtain greater insight into how brain aging has evolved, we compared age-related gene expression changes in the cortex of humans, rhesus macaques, and mice on a genome-wide scale. A small subset of gene expression changes are conserved in all three...

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PMID: 18830410
DOI: 10.1371/journal.pone.0003329

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