Article
Temporal dynamics and genetic control of transcription in the human prefrontal cortex.
Nature - 26 Oct 2011
Colantuoni Carlo, Lipska Barbara K, Ye Tianzhang, Hyde Thomas M, Tao Ran, Leek Jeffrey T, Colantuoni Elizabeth A, Elkahloun Abdel G, Herman Mary M, Weinberger Daniel R, Kleinman Joel E
Abstract excerpt
Previous investigations have combined transcriptional and genetic analyses in human cell lines, but few have applied these techniques to human neural tissue. To gain a global molecular perspective on the role of the human genome in cortical development, function and ageing, we explore the temporal dynamics and genetic control of transcription in human prefrontal cortex in an extensive series of post-mortem brains...
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