Article

Cell Population Effects in a Mouse Tauopathy Model Identified by Single Cell Sequencing

2019-09-16

Abstract excerpt

Neurodegenerative disorders are complex multifactorial diseases that have poorly understood selective vulnerabilities among discrete cell populations. We performed single cell RNA sequencing of whole hippocampi from the rTg4510 mouse tauopathy model, which expresses a P301L MAPT mutation at two time points—before and after the onset of pathology. One population of neurons showed a robust size reduction in both th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23dcfd96-7ada-5c20-9ee4-ef595b85e79b
DOI: 10.1101/771501

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell Population Effects in a Mouse Tauopathy Model Identified by Single Cell SequencingDOI 10.1101/771501Read

Single-cell RNA-seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson’s diseaseSemantic proximity Read

Spatial Transcriptome Profiling of Mouse Hippocampal Single Cell Microzone in Parkinson’s DiseaseSemantic proximity Read

Development of a versatile LCM-Seq method for spatial transcriptomics of fluorescently-tagged cholinergic neuron populationsSemantic proximity Read

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSPSemantic proximity Read

Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of NeurodegenerationSemantic proximity Read

Cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer’s diseaseSemantic proximity Read

Conserved gene signatures shared among <i>MAPT</i> mutations reveal defects in calcium signalingSemantic proximity Read

Expression weighted cell type enrichments reveal genetic and cellular nature of major brain disordersSemantic proximity Read

Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging and diseaseSemantic proximity Read

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening.Semantic proximity Read

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.Semantic proximity Read

Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1Semantic proximity Read