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Article

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening.

Molecules (Basel, Switzerland) - 24 Apr 2020

Chang Chia-Yu, Ting Hsiao-Chien, Liu Ching-Ann, Su Hong-Lin, Chiou Tzyy-Wen, Lin Shinn-Zong, Harn Horng-Jyh, Ho Tsung-Jung

Abstract excerpt

Neurodegenerative diseases represent a significant unmet medical need in our aging society. There are no effective treatments for most of these diseases, and we know comparatively little regarding pathogenic mechanisms. Among the challenges faced by those involved in developing therapeutic drugs for neurodegenerative diseases, the syndromes are often complex, and small animal models do not fully recapitulate the...

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Identifiers

PMID: 32344649
DOI: 10.3390/molecules25082000
PMCID: PMC7221979

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