Summix: A method for detecting and adjusting for population structure in genetic summary data.

doi:10.1016/j.ajhg.2021.05.016

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Article

Summix: A method for detecting and adjusting for population structure in genetic summary data.

American journal of human genetics - 1 Jul 2021

Arriaga-MacKenzie Ian S, Matesi Gregory, Chen Samuel, Ronco Alexandria, Marker Katie M, Hall Jordan R, Scherenberg Ryan, Khajeh-Sharafabadi Mobin, Wu Yinfei, Gignoux Christopher R, Null Megan, Hendricks Audrey E

Abstract excerpt

Publicly available genetic summary data have high utility in research and the clinic, including prioritizing putative causal variants, polygenic scoring, and leveraging common controls. However, summarizing individual-level data can mask population structure, resulting in confounding, reduced power, and incorrect prioritization of putative causal variants. This limits the utility of publicly available data,...

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PMID: 34157305
DOI: 10.1016/j.ajhg.2021.05.016
PMCID: PMC8322937

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