Article

Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligands

2025-08-24

Abstract excerpt

<h4>ABSTRACT</h4> Congenital hyperinsulinism (HI) is a rare genetic disease characterized by overproduction of insulin. One class of potential HI treatments is insulin receptor (IR) antagonists like S961 and Ins-AC-S2, peptides composed of binding segments for each of the IR sites capable of binding insulin: site 1 and site 2. Notably, S597 – containing the same IR binding segments as S961 but in the opposite ord...

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Literature Corpus work: 2378d4ec-8c66-58c2-b885-a9cc71c11f30
DOI: 10.1101/2025.08.23.671589

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