Article

How Structural Modifications of Insulin Icodec Contributes to Its Prolonged Duration of Action: A Structural and Biophysical Perspective

2023-11-16

Abstract excerpt

Insulin icodec of Novo Nordisk is a novel long-acting insulin analogue that exhibits an extended duration of action, providing a promising treatment option for individuals with diabetes. It has been reported that the incorporation of fatty acid moieties into insulin icodec plays a crucial role in its prolonged action, as these fatty acid chains facilitate the formation of stable hexameric structures, thereby delay...

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Literature Corpus work: 623cfd16-cf3a-5e4a-8f8a-e52179c58cae
DOI: 10.20944/preprints202311.1048.v1

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